PEC-19-34 AN OVERVIEW OF THERMAL ANALYSIS IN THEIR APPLICATION
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Dr. Alexis Morales
The term of thermal analysis is frequently used to describe analytical techniques to study the behaviour of a sample as a function of temperature. Solid state organic substances might exhibit different forms; some exist in more than one form or crystalline structure (polymorphs), others exhibit a structure in presence of solvents (pseudo-polymorph) and others show no order (amorphous). Thermal analysis is the best method for the characterization of thermodynamics relationship between true polymorphs, solvates or hydrates, and glass transition point from amorphous form. Thermoanalytical techniques such as:
Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), hyphenated thermogravimetric (TGA-MS and TGA-IR), and DSC microscopy offer quick and suitable interpretations that enable the optimization of
process at R&D and Manufacturing levels. Thermal analysis takes a relevance for pharmaceuticals in the study of physicochemical characteristics of the solid state which are involved in the polymorphism and pseudo-polymorphism. The physicochemical properties for active compound, such as solubility, melting point and vapor pressure are of great importance because they can affect the formulation characteristics, might impact the shelf life of the final drug product and even its bioavailability. Thermoanalytical instrumentation coupled with other instruments for physico-chemical analysis such as mass spectrometry, infrared spectroscopy, etc. are efficient tools to investigate the properties of polymeric materials as a function of temperature, time and mechanical load under a given sample atmosphere. Thermal analysis methodology and their respective applications will be presented.